liraglutide chemical structure liraglutide molecular weight
Sep 21, 2026 9:01 PM
# Exploring the Liraglutide Chemical Structure: A Technical Overview
When diving into the world of peptide research, understanding the building blocks of synthetic analogs is essential for any laboratory enthusiast. My personal interest in peptide chemistry led me to investigate the liraglutide chemical structure, a subject that highlights the intricate relationship between amino acid sequencing and molecular stability.
At its core, the liraglutide chemical structure is defined as a synthetic peptide analog of human glucagon-like peptide-1 (GLP-1). While the base native peptide is naturally occurring, this specific analog is modified to enhance its stability and longevity.
- Amino Acid Sequence: It consists of 31 amino acids. When comparing it to naturally occurring GLP-1, we see a crucial modification at position 34, where a lysin This article provides a detailed overview of Liraglutide, a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. It delves into … e residue is substituted with arginine.
- The Fatty Acid Chain: Another defining feature is the attachment of a C16 fatty acid chain (palmitoyl group) to the lysine residue at position 27 via a glutamic acid spacer. This structural addition is what distinguishes it from simpler chains and is a frequent topic in chemical documentation.
- Molecular Weight: Liraglutide is a novel once-daily human glucagon-like peptide (GLP)-1 analog in clinical use for the treatment of type 2 diabetes. To … The molecular weight of this peptide is approximately 3751.2 Da, reflecting its complex arrangement of 172 carbons, 265 hydrogens, 43 nitrogens, and 51 oxygens ChemSpider record containing structure, synonyms, properties, vendors and database links for liraglutide, 204656-20-2, … (C172H265N43O51).
Identifying the Technical Specs
For those looking to document their findings or organize their chemical 3D structure of Liraglutide showing one model from the NMR ensemble structure (PDB ID 4apd, Steengaard et al., 2013). Click here … inventories, having the Liraglutide: A Comprehensive Guide to its Pharmaceutical Properties correct technical data is non-negotiable.
Many researchers often ask, "is liraglutide a biologic?" Given its production through recombinant DNA technology—specifically utilizing *Saccharomyces cerevisiae*—it is considered a biologic or a peptide-based synthetic protein. Understanding its liraglutide chemical name—*N-epsilon-(gamma-L-glutamyl(N-alpha-hexadecanoyl))-Lys27-Arg34-GLP-1(7-37)*—is helpful for precise identification.
If you are cataloging your structural data, the liraglutide smiles string is: *CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)...* (Note: This is a truncated representation for brevity; full strings are (a) Liraglutide primary structure; 97% amino acid - ResearchGate typically retrieved from databases like ChemSpid PDB-101: Diabetes Mellitus: Diabetes Mellitus: undefined: Liraglutide er or PubChem).
Practical Observations in the Lab
During my time exploring the physical properties of this peptide, I have noted several points relevant to handling and storage:
1. Liraglutide solubility in water: Like many lipopeptides, the solubility profile is influenced by the C16 fatty acid chain. It is typically prepared in basic, aqueous solutions, as standard low-pH water may not yield optimal dissolution. Researchers often use a small amount of physiological buffer to ensure complete transition into solution.
2. Structural Integrity: The PDB ID 4APD provides a snapshot of the NMR ensemble structure. Reviewing this model is an excellent way for visual learners to grasp how the fatty acid chain affects the peptide’s conformation.
3. The Innovator: The evolution of this peptide, originally developed by Novo Nordisk, set a standard for synthetic analogs in this category.
Summary of Data Points
For those curating a reference library However, your browser does not support WebGL, so a static image is shown instead. To see the interactive view of the structure, … , refer to the following summary:
Attribute
Specification
Peptide Length
31 amino acids
Chemical Formula
C172H265N43O51
Primary Modification
C16 side chain at Lys27; Arg swap at Pos 34
CAS Registry Number
204656-20-2
By focusing on the purity and the precision of the liraglutide amino acid sequence, one gains a deeper appreciation for how even minor modifications at the molecular level can alter the functional profile of a compound. Whether you are mapping out the liraglutide number of amino acids for a presentation or simply documenting structural nuances for your records, the attention to detail in these specifications remains the bedrock of high-quality peptide study.
Always ensure that your research is conducted with proper documentation and that you adhere to the specific handling protocols outlined by chemical suppliers to maintain the integrity of your material.
# Exploring the Liraglutide Chemical Structure: A Technical Overview
When diving into the world of peptide research, understanding the building blocks of synthetic analogs is essential for any laboratory enthusiast. My personal interest in peptide chemistry led me to investigate the liraglutide chemical structure, a subject that highlights the intricate relationship between amino acid sequencing and molecular stability.
At its core, the liraglutide chemical structure is defined as a synthetic peptide analog of human glucagon-like peptide-1 (GLP-1). While the base native peptide is naturally occurring, this specific analog is modified to enhance its stability and longevity.
- Amino Acid Sequence: It consists of 31 amino acids. When comparing it to naturally occurring GLP-1, we see a crucial modification at position 34, where a lysin This article provides a detailed overview of Liraglutide, a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. It delves into … e residue is substituted with arginine.
- The Fatty Acid Chain: Another defining feature is the attachment of a C16 fatty acid chain (palmitoyl group) to the lysine residue at position 27 via a glutamic acid spacer. This structural addition is what distinguishes it from simpler chains and is a frequent topic in chemical documentation.
- Molecular Weight: Liraglutide is a novel once-daily human glucagon-like peptide (GLP)-1 analog in clinical use for the treatment of type 2 diabetes. To … The molecular weight of this peptide is approximately 3751.2 Da, reflecting its complex arrangement of 172 carbons, 265 hydrogens, 43 nitrogens, and 51 oxygens ChemSpider record containing structure, synonyms, properties, vendors and database links for liraglutide, 204656-20-2, … (C172H265N43O51).
Identifying the Technical Specs
For those looking to document their findings or organize their chemical 3D structure of Liraglutide showing one model from the NMR ensemble structure (PDB ID 4apd, Steengaard et al., 2013). Click here … inventories, having the Liraglutide: A Comprehensive Guide to its Pharmaceutical Properties correct technical data is non-negotiable.
Many researchers often ask, "is liraglutide a biologic?" Given its production through recombinant DNA technology—specifically utilizing *Saccharomyces cerevisiae*—it is considered a biologic or a peptide-based synthetic protein. Understanding its liraglutide chemical name—*N-epsilon-(gamma-L-glutamyl(N-alpha-hexadecanoyl))-Lys27-Arg34-GLP-1(7-37)*—is helpful for precise identification.
If you are cataloging your structural data, the liraglutide smiles string is: *CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)...* (Note: This is a truncated representation for brevity; full strings are (a) Liraglutide primary structure; 97% amino acid - ResearchGate typically retrieved from databases like ChemSpid PDB-101: Diabetes Mellitus: Diabetes Mellitus: undefined: Liraglutide er or PubChem).
Practical Observations in the Lab
During my time exploring the physical properties of this peptide, I have noted several points relevant to handling and storage:
1. Liraglutide solubility in water: Like many lipopeptides, the solubility profile is influenced by the C16 fatty acid chain. It is typically prepared in basic, aqueous solutions, as standard low-pH water may not yield optimal dissolution. Researchers often use a small amount of physiological buffer to ensure complete transition into solution.
2. Structural Integrity: The PDB ID 4APD provides a snapshot of the NMR ensemble structure. Reviewing this model is an excellent way for visual learners to grasp how the fatty acid chain affects the peptide’s conformation.
3. The Innovator: The evolution of this peptide, originally developed by Novo Nordisk, set a standard for synthetic analogs in this category.
Summary of Data Points
For those curating a reference library However, your browser does not support WebGL, so a static image is shown instead. To see the interactive view of the structure, … , refer to the following summary:
By focusing on the purity and the precision of the liraglutide amino acid sequence, one gains a deeper appreciation for how even minor modifications at the molecular level can alter the functional profile of a compound. Whether you are mapping out the liraglutide number of amino acids for a presentation or simply documenting structural nuances for your records, the attention to detail in these specifications remains the bedrock of high-quality peptide study.
Always ensure that your research is conducted with proper documentation and that you adhere to the specific handling protocols outlined by chemical suppliers to maintain the integrity of your material.