linaclotide chemical structure Linaclotide other names
Sep 21, 2026 11:56 PM
# Exploring the Linaclotide chemical structure: A Technical Perspective
As an enthusiast in the field of peptide research, I have spent significant time examining the molecular architecture of various synthetic compounds. Among these, the linaclotide chemical structure stands out due to its unique, highly ordered configuration The molecular structure of linaclotide (left) and cyclosporine (right), one of the examples of orally … . Understanding this molecule is essential for anyone interested in the nuance of peptide chemistry and the specific biochemical frameworks that dictate how these compounds interact with their respective targets.
Linaclotide is a synthetic 14-amino acid peptide that exhibits a sophisticated cyclic structure. When studying the linaclotide molecule, the most striking feature is the presence of three conserved disulfide bonds, which are formed between six cysteine residues. These sulfur bridge interactions create a rigid tertiary structure that is crucial for its stability.
In personal comparative analysis, the linaclotide molecular weight is often cited around 1526.73 g/mol (with a monoisotopic mass of 1525.3899 Da). The chemi 202811Orig1s000 - Food and Drug Administration cal formula is C59H79N15O21S6. This specific arrangement is why researchers emphasize its 3 disulfide (-S—S-) bonds when reviewing the compound's structural integrity.
What is the Linaclotide Peptide?
For those asking, "linaclotide what is it?", it is a synthetic homolog of heat-stable (ST) enterotoxin. It acts as an agonist of the guanylate cyclase-C (GC-C) receptor. From a laboratory handling perspective, it is typically supplied as a powder or lyophilized powder, requiring careful documentation of its CAS number, 851199-59-2, for standard reference.
Investigating the Mechanism
The linaclotide mode of action revolves around its binding to the GC-C receptor. Unlike smaller molecules, this 14-amino acid cyclic peptide provides a specific interaction pattern that is foundational for its activity. It functions effectively by mimicking the endogenous ligands that activate the intracellula Linaclotide (Standard) | C59H79N15O21S6 | CID 92044408 - structure, chemical names, physical and … r pathways associated with the guanylate cyclase-C enzyme.
Know about technical details of Linaclotide like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects …
Nomenclature and Identification
When navigating scientific databases, it helps to be aware of the different identifiers used for this compound:
* Brand names: While often associated with the trade name Linzess in various distributed forms, research-grade samples are typically labeled by their technical name.
* Other names: Sometimes referred to as a synthetic peptide anal Jul 25, 2018 · Drug molecule design based on structural information plays a crucial role and the activity of linaclotide still need to … ogue, it is cataloged in portals like ChemSpider or PubChem.
* Common name: Linaclotide is the universally accepted Linaclotide, a 14-amino acid synthetic peptide, is a minimally absorbed agonist of the guanylate cyclase type-C (GC-C) receptor, … scientific nomenclature across internatio Linaclotide (acetate) | C61H83N15O23S6 | CID 171714161 - PubChem nal pharmacopeia.
Technical Characteristics for Researchers
When synthesizing or evaluating the purity of this compound (often looking for 95% HPLC purity), one must account for its physical properties. Its rigid, disulfide-linked shape is sensitive to environmental factors. Unlike linear sequences, the cyclic nature of the linaclotide peptide necessitates strict adherence to cold-chain storage and handling to prevent degradation of those essential disulfide bridges.
In my own documentation of peptide characterization, I find that acknowledging the distinction between the base peptide and the acetate form—often seen as C61H83N15O23S6—is vital for accuracy in experimental logs. As a researcher, focusing on these precise chemical parameters allows for more reliable observations in comparative structural studies. By maintaining strict protocols regarding structure-activity relationships, one can better understand the elegance of such complex synthetic entities.
# Exploring the Linaclotide chemical structure: A Technical Perspective
As an enthusiast in the field of peptide research, I have spent significant time examining the molecular architecture of various synthetic compounds. Among these, the linaclotide chemical structure stands out due to its unique, highly ordered configuration The molecular structure of linaclotide (left) and cyclosporine (right), one of the examples of orally … . Understanding this molecule is essential for anyone interested in the nuance of peptide chemistry and the specific biochemical frameworks that dictate how these compounds interact with their respective targets.
Linaclotide is a synthetic 14-amino acid peptide that exhibits a sophisticated cyclic structure. When studying the linaclotide molecule, the most striking feature is the presence of three conserved disulfide bonds, which are formed between six cysteine residues. These sulfur bridge interactions create a rigid tertiary structure that is crucial for its stability.
In personal comparative analysis, the linaclotide molecular weight is often cited around 1526.73 g/mol (with a monoisotopic mass of 1525.3899 Da). The chemi 202811Orig1s000 - Food and Drug Administration cal formula is C59H79N15O21S6. This specific arrangement is why researchers emphasize its 3 disulfide (-S—S-) bonds when reviewing the compound's structural integrity.
What is the Linaclotide Peptide?
For those asking, "linaclotide what is it?", it is a synthetic homolog of heat-stable (ST) enterotoxin. It acts as an agonist of the guanylate cyclase-C (GC-C) receptor. From a laboratory handling perspective, it is typically supplied as a powder or lyophilized powder, requiring careful documentation of its CAS number, 851199-59-2, for standard reference.
Investigating the Mechanism
The linaclotide mode of action revolves around its binding to the GC-C receptor. Unlike smaller molecules, this 14-amino acid cyclic peptide provides a specific interaction pattern that is foundational for its activity. It functions effectively by mimicking the endogenous ligands that activate the intracellula Linaclotide (Standard) | C59H79N15O21S6 | CID 92044408 - structure, chemical names, physical and … r pathways associated with the guanylate cyclase-C enzyme.
Know about technical details of Linaclotide like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects …Nomenclature and Identification
When navigating scientific databases, it helps to be aware of the different identifiers used for this compound:
* Brand names: While often associated with the trade name Linzess in various distributed forms, research-grade samples are typically labeled by their technical name.
* Other names: Sometimes referred to as a synthetic peptide anal Jul 25, 2018 · Drug molecule design based on structural information plays a crucial role and the activity of linaclotide still need to … ogue, it is cataloged in portals like ChemSpider or PubChem.
* Common name: Linaclotide is the universally accepted Linaclotide, a 14-amino acid synthetic peptide, is a minimally absorbed agonist of the guanylate cyclase type-C (GC-C) receptor, … scientific nomenclature across internatio Linaclotide (acetate) | C61H83N15O23S6 | CID 171714161 - PubChem nal pharmacopeia.
Technical Characteristics for Researchers
When synthesizing or evaluating the purity of this compound (often looking for 95% HPLC purity), one must account for its physical properties. Its rigid, disulfide-linked shape is sensitive to environmental factors. Unlike linear sequences, the cyclic nature of the linaclotide peptide necessitates strict adherence to cold-chain storage and handling to prevent degradation of those essential disulfide bridges.
In my own documentation of peptide characterization, I find that acknowledging the distinction between the base peptide and the acetate form—often seen as C61H83N15O23S6—is vital for accuracy in experimental logs. As a researcher, focusing on these precise chemical parameters allows for more reliable observations in comparative structural studies. By maintaining strict protocols regarding structure-activity relationships, one can better understand the elegance of such complex synthetic entities.